Product Name :
MC3482
Description:
MC3482 is a specific sirtuin5 (SIRT5) inhibitor.
CAS:
Molecular Weight:
618.68
Formula:
C33H38N4O8
Chemical Name:
(2S)-2-[(benzyloxy)carbonyl]amino-4-[(5S)-5-[(benzyloxy)carbonyl]amino-5-(phenylcarbamoyl)pentyl]carbamoylbutanoic acid
Smiles :
OC(=O)[C@H](CCC(=O)NCCCC[C@H](NC(=O)OCC1C=CC=CC=1)C(=O)NC1C=CC=CC=1)NC(=O)OCC1C=CC=CC=1
InChiKey:
LDCYHYVNYRUUOL-NSOVKSMOSA-N
InChi :
InChI=1S/C33H38N4O8/c38-29(20-19-28(31(40)41)37-33(43)45-23-25-14-6-2-7-15-25)34-21-11-10-18-27(30(39)35-26-16-8-3-9-17-26)36-32(42)44-22-24-12-4-1-5-13-24/h1-9,12-17,27-28H,10-11,18-23H2,(H,34,38)(H,35,39)(H,36,42)(H,37,43)(H,40,41)/t27-,28-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Exendin-4 In Vitro
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MC3482 is a specific sirtuin5 (SIRT5) inhibitor.|Product information|Molecular Weight: 618.68|Formula: C33H38N4O8|Chemical Name: (2S)-2-[(benzyloxy)carbonyl]amino-4-[(5S)-5-[(benzyloxy)carbonyl]amino-5-(phenylcarbamoyl)pentyl]carbamoylbutanoic acid|Smiles: OC(=O)[C@H](CCC(=O)NCCCC[C@H](NC(=O)OCC1C=CC=CC=1)C(=O)NC1C=CC=CC=1)NC(=O)OCC1C=CC=CC=1|InChiKey: LDCYHYVNYRUUOL-NSOVKSMOSA-N|InChi: InChI=1S/C33H38N4O8/c38-29(20-19-28(31(40)41)37-33(43)45-23-25-14-6-2-7-15-25)34-21-11-10-18-27(30(39)35-26-16-8-3-9-17-26)36-32(42)44-22-24-12-4-1-5-13-24/h1-9,12-17,27-28H,10-11,18-23H2,(H,34,38)(H,35,39)(H,36,42)(H,37,43)(H,40,41)/t27-,28-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 130 mg/mL (210.Ziritaxestat web 12 mM).PMID:32804775 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MC3482 inhibits sirtuin5. 50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells.|Products are for research use only. Not for human use.|
