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Of silk fibroin substrata happen to be carried out so far. five. Conclusions The presence with the RGD peptide ligand isn’t sufficient to promote a statistically significant enhancement of cell attachment and development on substrata of Bombyx mori silk fibroin, when the study model technique is human corneal limbal epithelial (HLE) cells. Although a trend towards an improvement within the attachment of cells could be noted, other things may possibly impact the adhesion ligand efficacy, warranting additional investigations. References 1. 2. 3. four. 5. six. 7. 8. Minoura, N.; Tsukada, M.; Nagura, M. Physico-chemical properties of silk fibroin membrane as a biomaterial. Biomaterials 1990, 11, 43034. Minoura, N.; Aiba, S.; Higuchi, M.; Gotoh, Y.; Tsukada, M.; Imai, Y. Attachment and growth of fibroblast cells on silk fibroin. Biochem. Biophys. Res. Commun. 1995, 208, 51116. Minoura, N.; Aiba, S.; Gotoh, Y.; Tsukada, M.; Imai, Y. Attachment and development of cultured fibroblast cells on silk protein matrices. J. Biomed. Mater. Res. 1995, 29, 1215221. Altman, G.H.; Diaz, F.; Jakuba, C.; Calabro, T.; Horan, R.L.; Chen, J.; Lu, H.; Richmond, J.; Kaplan, D.L. Silk-based biomaterials. Biomaterials 2003, 24, 40116. Wang, Y.; Kim, H.-J.; Vunjak-Novakovic, G.; Kaplan, D.L. Stem cell-based tissue engineering with silk biomaterials. Biomaterials 2006, 27, 6064082. Vepari, C.; Kaplan, D.L. Silk as a biomaterial. Prog. Polym. Sci. 2007, 32, 991007. Hakimi, O.; Knight, D.P.; Vollrath, F.; Vadgama, P. Spider and mulberry silkworm silks as compatible biomaterials. Composites B 2007, 38, 32437. Wang, X.; Cebe, P.; Kaplan, D.L. Silk Proteins–Biomaterials and bioengineering. In Protein Engineering Handbook; Lutz, S., Bornscheuer, U.T., Eds.; Wiley-VCH Verlag: Weinheim, Germany, 2009; pp. 93959.J. Funct. Biomater. 2013, four 9. 10. 11. 12. 13. 14. 15.16. 17.18.19. 20. 21. 22.Myc-tag Antibody Autophagy 23. 24. 25.26. 27.Murphy, A.R.; Kaplan, D.L. Biomedical applications of chemically-modified silk fibroin. J. Mater. Chem. 2009, 19, 6443450. Hardy, J.G.; Scheibel, T.R. Composite components depending on silk proteins. Prog. Polym. Sci. 2010, 35, 1093115. Numata, K.; Kaplan, D.L. Silk-based delivery systems of bioactive molecules. Adv. Drug Deliv. Rev. 2010, 62, 1497508. Pritchard, E.M.; Kaplan, D.L. Silk fibroin biomaterials for controlled release drug delivery. Professional Opin. Drug Deliv. 2011, 8, 79711. Wenk, E.; Merkle, H.P.; Meinel, L. Silk fibroin as a vehicle for drug delivery applications.Lysyl endopeptidase, Achromobacter sp Technical Information J.PMID:28322188 Handle. Rel. 2011, 150, 12841. Zhang, Y.-Q. Applications of organic silk protein sericin in biomaterials. Biotechnol. Adv. 2002, 20, 9100. Kundu, S.C.; Dash, B.C.; Dash, R.; Kaplan, D.L. Natural protective glue protein, sericin bioengineered by silkworms: Prospective for biomedical and biotechnological applications. Prog. Polym. Sci. 2008, 33, 998012. Armato, U.; Dal PrI.; Chiarini, A.; Freddi, G. Will silk fibroin nanofiber scaffolds ever hold a , valuable spot in translational regenerative medicine Int. J. Burn Trauma 2011, 1, 273. Chirila, T.V.; Barnard, Z.; Zainuddin; Harkin, D.G.; Schwab, I.R.; Hirst, L.W. Bombyx mori silk fibroin membranes as possible substrata for epithelial constructs employed within the management of ocular surface disorders. Tissue Eng. Element A 2008, 14, 1203211. Ghassemifar, R.; Redmond, S.; Zainuddin; Chirila, T.V. Advancing towards a tissue-engineered tympanic membrane: Silk fibroin as a substratum for increasing human eardrum keratinocytes. J. Biomater. Appl. 2010, 24, 59106. Madden, P.W.; Lai, J.N.X.; George, K.A.; Giovenco,.

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