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A downstream effector of oncogenic K-ras in lung tumors. Cancer Res
A downstream effector of oncogenic K-ras in lung tumors. Cancer Res 71:2087097. Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F, Wu ZJ, Krall JA, Bierie B, and Guo W et al. (2013) Protein kinase C a is actually a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell 24:34764. Tang J, Salama R, Gadgeel SM, Sarkar FH, and Ahmad A (2013) Erlotinib resistance in lung cancer: existing progress and future perspectives. Front Pharmacol four:15. Tekle C, Giovannetti E, Sigmond J, Graff JR, Smid K, and Peters GJ (2008) Molecular pathways involved in the synergistic interaction from the PKC beta inhibitor enzastaurin using the antifolate pemetrexed in non-small cell lung cancer cells. Br J Cancer 99:75059. Tonetti DA, Chisamore MJ, Grdina W, Schurz H, and Jordan VC (2000) Steady transfection of protein kinase C alpha cDNA in hormone-dependent breast cancer cell lines. Br J Cancer 83:78291. Vansteenkiste J, Ramlau R, von Pawel J, San Antonio B, Eschbach C, Szczesna A, Kennedy L, Visseren-Grul C, Chouaki N, and Reck M (2012) A phase II randomized study of cisplatin-pemetrexed plus either enzastaurin or placebo in chemonaive individuals with advanced non-small cell lung cancer. Oncology 82:259. Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, and Kazanietz MG (2014) Transcriptional regulation of oncogenic protein kinase C(PKC by STAT1 and Sp1 proteins. J Biol Chem 289:198239838. Methods DK, Kukoly CA, deVente J, Hooker JL, Bryant WO, Posekany KJ, Fletcher DJ, Cook PP, and Parker PJ (1995) MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and show a more aggressive neoplastic phenotype. J Clin Invest 95:1906915. Willey CD, Xiao D, Tu T, Kim KW, Moretti L, Niermann KJ, Tawtawy MN, Quarles CC, and Lu B (2010) Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation. Int J Radiat Oncol Biol Phys 77:1518526.Authorship ContributionsParticipated in analysis style: Abera, Kazanietz. Carried out experiments: Abera. Performed information evaluation: Abera, Kazanietz. Wrote or Dopamine Receptor review contributed for the writing of your manuscript: Abera, Kazanietz.
Zhang et al. Parasites Vectors (2015)eight:37 DOI ten.1186/s13071-015-0650-RESEARCHOpen AccessAn association of Aquaporin-4 with all the immunoregulation of liver pathology in mice infected with Schistosoma japonicumWeiwei Zhang1, Jifeng Zhu1, Xian Song1, Zhipeng Xu1, Xue Xue2, Xiaojun Chen1, Xiaowei Yang1, Yong Li1, Xiaoxiao Dong1, Sha Zhou1, Wei Li1, Yingying Qian3, Feng Liu1 and Chuan Su1*AbstractBackground: CXCR6 MedChemExpress Schistosomiasis is really a chronic parasitic illness that impacts about 200 million people today. In Schistosomiasis japonica and mansoni, parasite eggs have been trapped in host liver and stimulated the CD4+T cell responses to regulate the formation with the granulomas. Subsequently, excessive granulomatous response in some heavily, and/or repeatedly infected people could lead to chronic liver fibrosis and circulatory impairment. Therefore, elucidation of the mechanisms of these responses is not going to only offer more information and facts to better comprehend the mechanisms of your immunoregulation in schistosomiasis, but in addition enable to style new therapies to handle granuloma-associated immunopathology. The function of aquaporin-4 (AQP4) in water transport has been extensively investigated within the central nervous technique (CNS). Lately, research have show.

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