**Background** Chronic kidney disease (CKD) is a progressive condition characterized by the gradual loss of kidney function, which often leads to the accumulation of potassium in the blood, a condition…
**Background** Platelet-derived growth factor receptors (PDGFRs) are transmembrane tyrosine kinases that play critical roles in cell proliferation, migration, and survival. Dysregulation of these receptors is implicated in various pathological conditions,…
**Background** Metabolic disorders, such as diabetes, and various forms of cancer remain significant global health challenges. In the context of metabolic health, the activation of the insulin signaling pathway is…
**Background** Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperplasia and the infiltration of immune cells. The pathogenesis of this condition is heavily driven by the IL-23/IL-17 axis,…
The identification and management of aberrant left hepatic arteries (ALHAs) during gastrectomy remain a critical challenge in minimally invasive upper gastrointestinal surgery. ALHAs, which originate from the left gastric artery…
The integrity of extracellular vesicles (EVs) is paramount for accurate functional and mechanistic studies, as any alteration in size, charge, or morphology can significantly impact their biological behavior. Conventional labeling…
The advancement of biosensing technology demands not only high sensitivity but also exceptional specificity and reliability, particularly in clinical diagnostics where false positives can lead to unnecessary interventions. This study…
The identification of potent, selective, and brain-penetrant phosphodiesterase 2 (PDE2) inhibitors remains a critical goal in the development of therapeutics for cognitive disorders. This study presents the comprehensive preclinical evaluation…
Mechanical ventilation is a vital intervention in critical care, yet it remains associated with significant risks when not precisely individualized. Excessive lung stress from high pressures or volumes can lead…
Wearable piezoresistive sensors with high sensitivity and adaptability are crucial for real-time monitoring of human physiological signals in smart healthcare systems. This study reports the development of an ultra-sensitive, flexible,…