Cynomolgus LY6G6D Protein 2063

Additional Information:
accession XP_045246087|express systemHEK293|product tagN-hFc|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundLY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.|molecular weightThe protein has a predicted MW of 34.65 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Cynomolgus LY6G6D Protein 2063proteinSize and concentration100, 500g and liquidFormLiquidStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped with dry ice.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceLY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.Protein namesLymphocyte antigen 6 complex locus protein G6d (Protein Ly6-D) (Megakaryocyte-enhanced gene transcript 1 protein)Gene namesLY6G6D,LY6G6D C6orf23 G6D MEGT1 NG25Mass9606DaSubellular locationCell membrane ; Lipid-anchor, GPI-anchor. Cell projection, filopodium .TissuesExpressed in the adult lung, and in fetal liver, lung, kidney, brain and spleen.StructureHomodimer.Post-translational modificationO-glycosylated.Target Relevance information above includes information from UniProt accession: O95868The UniProt Consortium|