Human Neogenin Protein 2621

Additional Information:
accession Q92859|express systemHEK293|product tagC-hFc|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundNeogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axon guidance and cell survival.|molecular weightThe protein has a predicted MW of 144.37 kDa. Due to glycosylation, the protein migrates to 150-180 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human Neogenin Protein 2621proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceNeogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axon guidance and cell survival.Protein namesNeogenin (Immunoglobulin superfamily DCC subclass member 2)Gene namesNEO1,NEO1 IGDCC2 NGNProtein familyImmunoglobulin superfamily, DCC familyMass9606DaFunctionMulti-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.Subellular locationCell membrane; Single-pass type I membrane protein.TissuesWidely expressed and also in cancer cell lines.StructureInteracts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7.DomainThTarget Relevance information above includes information from UniProt accession: Q92859The UniProt Consortium|